Invited speakers

Scientific Program

Friday, May 4, 2012

8:30 – 8:40

Invitation by Zdeněk Havlas, IOCB AS CR director

Session 1.  Proteins in Membranes

Chairman Andreas Plueckthun

1.1 08:40 – 09:20 Daniel Mueller (ETH Zurich, CH)
Reversible un- and refolding of single transmembrane beta-barrel proteins into membrane bilayers

1.2 09:20 – 10:00 Gunnar Von Heijne (Univeristy of Stockholm, SE)
Energetics and dynamics of translocon-mediated membrane-protein insertion

1.3 10:00 – 10:40 Kvido Strisovsky (IOCB AS CR, Prague, CZ)
Proteolysis in lipid membrane: substrate specificity and mechanism of rhomboids

10:40 – 11:00  Coffee Break

1.4 11:00 – 11:40 Anne Ulrich (Universitat Karlsruhe, DE)
Charge zippers: a novel motif for folding and self-assembly of membrane proteins

1.5 11:40 – 12:20 Valerie Daggett (University of Washington, Seattle, USA)
Proteins in different environments: the effect of osmolytes, lipids, and neighboring proteins on protein unfolding

12:30 – 14:00  Lunch

Session 2.  Proteins in osmolytes, denaturants and salts

Chairman Valerie Daggett

2.1 14:00 – 14:40 George Rose (Johns Hopkins University, Baltimore, USA)
Protein domains – a thermodynamic definition

2.2 14:40 – 15:20 George Makhatadze I (Rensselaer Polytechnic Institute, USA)
Protein folding and aggregation: linking computation and experiment

2.3 15:20 – 16:00  Jim Warwicker (Manchester Interdisciplinary Biocentre, UK)
Continuum electrostatics models for biology

16:00 – 16:20  Coffee Break

2.4 16:20 – 17:00 Vladimir Uversky (University of South Florida, Tampa, USA)
Intrinsically disordered proteins in salted water and thick soup

2.5 17:00 – 17:40  Stefano Gianni (University of Roma, IT)
Nearly identical, yet very different: addressing the folding of proteins with increasing degree of sequence identities but different structure and function

19:30 – 23:00 Poster Session

Saturday May 5th

Session 2.  Proteins in osmolytes, denaturants and salts

Chairman Valerie Dagett

2.6 08:30 – 09:10  Dietmar Paschek (Universitat Rostock, DE)
Computer simulation of the folding/unfolding equilibrium of the Trp-Cage miniprotein: understanding the effects of pressure and denaturants.

2.7 09:10 – 09:50  Jan Heyda (Helmholtz-Zentrum für Materialien und Energie GmbH, Berlin, DE) Different denaturation pathways of Trp-Cage Minipeptide triggered by urea and guanidinium chloride

9:50 – 10:10 Coffee break

Session 3.  Proteins in cells

Chairman Peter Tompa

3.1 10:10 – 10:50  Phil Selenko (FMP Berlin, DE)
Residue-resolved IDP dynamics in live mammalian cells

3.2 10:50 – 11:30  Mikael Oliveberg (University of Stockholm, SE)
In cell NMR of the ALS-associated protein SOD1

3.3 11:30 – 12:10  Michele Vendruscolo (University of Cambridge, UK)
Characterization of free energy landscapes of proteins using NMR spectroscopy

12:10 – 14:30  Lunch

Session 4. Proteins in crystals, complexes, and aggregates

Chairman George Rose

4.1 14:30 – 15:10  Martin Vabulas (Goethe University Frankfurt, DE)
Amyloid proteotoxicity

4.2 15:10 – 15:50  Peter Tompa (VrijeUniversiteit Brussel, BE)
Structure and function of intrinsically disordered chaperones

15:50 – 16:10  Coffee Break

4.3 16:10 – 16:50  Andreas Plueckthun (Universitat Zurich, CH)
Engineering specific and sensitive detectors from synthetic binding proteins

4.4 16:50 – 17:30  Zygmunt Derewenda (University of Virginia, USA)
Are protein crystals just convenient and useful artifacts

4.5 17:30 – 18:10  Robert Best (Cambridge University, UK)

Passive role of a chaperonin cavity in modulating folding kinetics and preventing protein misfolding

18:10  General discussion and concluding remarks

19:30 – 23:00 Dinner at a steamboat – Sightseeing from Vltava River

Program Overwiew