Scientific Program

Invited speakers

Jane DYSON      
(The Scripps research Institute, USA)    
 
Peter WRIGHT
(The Scripps research Institute,USA)
 
A. Keith DUNKER
(Indiana University, USA)
 
Dana REICHMANN
(The Hebrew University, Israel)
 
Modesto OROZCO 
(IRB Barcelona, Spain)
 
Jacqueline MATTHEWS 
(University of Sydney, Australia)  
 
Nikolay DOKHOLYAN 
(University of NC, Chapel Hill, USA)
 
Chris CHIPOT                
(University of Illinois, USA)
 
Mikael OLIVEBERG
(Stockholm University, Sweden)   
 
Janusz BUJNICKI        
(IMCBIn Warsaw, Poland)
 
Michele VENDRUSCOLO
(Cambridge University, UK)  
 
Alex WLODAWER
(NCI, USA)
 
Tomas OBSIL        
(Charles University, Prague, CZ)  
 
B. Montgomery PETTITT
(University of Texas, USA)
 
Edward TRIFONOV
(University of Haifa, IL)
 
Richard STEFL      
(Masaryk University, Brno, CZ)  
 
Neil FERGUSON                
(UCD Dublin, Ireland)  
 
Vladimir SKLENAR    
(Masaryk University, Brno, CZ)
 
Torsten SCHWEDE
(Universitat Basel, Switzerland)
 
Ora SCHUELER-FURMAN
(Hebrew University, Jerusalem, IL)

 

 

 

 

Scientific Program

Friday May 9th 2014

15:00 - 15:15

Invitation:  Zdeněk Hostomsky, IOCB AS CR director

Opening:  Jiri Vondrasek IOCB AS CR

 

 

Session 1.  Protein-Protein Interactions

Chairman: Chris Chipot

 

1.1 15:15-16:00 A. Keith Dunker

Disordered Protein and Developmental Biology

1.2 16:00-16:45 Alexander Wlodawer

Plant proteins with medically important properties: structural studies of three members of the β-trefoil family that function as serine protease inhibitors or as lectins

 

16:45-17:00 Coffee break

 

1.3 17:00-17:45  Torsten Schwede

Comparative protein quaternary structure modelling using evolutionary interaction fingerprints

1.4. 17:45-18:10 Moran Jerabek-Willemsen

MicroScale Thermophoresis: Interaction analysis and beyond

 

18:15-20:00  Welcome drink, dinner

 

Saturday May 10th, 2014

Session 2.  Interactions within proteins and Interactions of Proteins with ligands

Chairman: Mikael Oliveberg

 

2.1 8:30-9:15 Nikolay Dokholyan

Controlling allosteric networks in proteins

2.2 9:15-10:00 Jacqueline Matthews

Selectivity and synergy in binding by modular linear motifs

 

PPS Selected talk

10:00-10:30 Kvido Stříšovský
Structural basis of rhomboid intramembrane protease specificity and mechanism revealed by X-ray crystallographic analysis of rhomboid:substrate-peptide complexes

 

10:30-11:00  Coffee break

 

2.3 11:00-11:45 Modesto Orozco

Functional aspects of protein dynamics

2.4 11:45-12:30 Vladimir Sklenar

Intrinsically Disordered Proteins – Atomic Resolution Characterization of Transient Interactions

2.5 12:30-13:15 Ora Schueler-Furman

Peptide-mediated interactions: characterization, modeling and manipulation

 

13:15-14:30  Lunch

 

Session 3.  Protein-Protein Interactions

Chairman Jane Dyson

 

3.1 14:30-15:15 Neil Ferguson

High resolution studies of the molecular handshake between a disordered viral protein and its human binding-partner

3.2 15:15-16:00 Peter Wright

Functional interactions of intrinsically disordered proteins in dynamic signaling networks

3.3 16:00-16:45 Chris Chipot

Efficient determination of protein-protein standard binding free energies with a computational
microcalorimeter

 

16:45-17:10 Coffee break

 

3.4 17:10-17:55 Tomas Obsil

14-3-3 proteins and mechanisms of their functions

3.5 17:55-18:35 Richard Stefl

Dynamic recruitment of processing factors to the site of transcription.

 

19:30 – 23:00 Poster Session

 

Sunday May 11th, 2014

Session 4.  Protein aggregates

Chairman Peter Wright

 

4.1 8:30-9:15 B. Montgomery Pettitt

Aggregation, collapse and disorder: Model systems

4.2 9:15-10:00 Mikael Oliveberg

In-cell thermodynamics

 

PPS selected talk
10:00-10:30 Lajos Kalmar
Functional evolutuon of intrinsically disordered proteins

 

10:30-10:50 Coffee break

 

4.3 10:50-11:35 Michele Vendruscolo

Characterisation of Protein Dynamics by Combining NMR Spectroscopy and Molecular Dynamics Simulations

4.4 11:35-12:20 Dana Reichmann

Unfoldomics of the cellular stress response: How do Intrinsically disordered chaperones work?

 

12:20-13:30 Lunch

 

Session 5.  Protein – Nucleic Acid Interactions

Chairman Michele Vendruscolo

 

5.1 13:30-14:15 Edward N. Trifonov

Strong nucleosomes - towards major revision of views on chromatin.

5.2 14:15-15:00 Janusz Bujnicki

3D Modeling of protein-RNA complex structures

5.3 15:00-15:45 Jane H Dyson

Dynamics and specificity in protein-nucleic acid interactions.

 

15:45-16:30  General discussion and concluding remarks

16:45-18:00 Vila Lanna- Prague Castle-Prague Castle Gardens Walking Tour

18:00-21:00 Conference dinner at Vila Richter (Prague Castle vineyard)