Scientific Program
Thursday 4 May 2023
Opening: Jiří Vondrášek IOCB Prague, Mikael Oliveberg Stockholm University, Michele Vendruscolo University of Cambridge
Online version of Conference booklet.
Session 1 (18:00 - 19:30)
Chairman: Michele Vendruscolo
18:00 - 18:45 Alan Fersht - Gonville and Caius College, University of Cambridge, UK
From engineering mutations to study folding and stability to drugging p53 oncogenic mutants
18:45 - 19:30 Ken Dill - Stony Brook University, USA
How protein folding may hold the key to origin of life
19:30 - 21:00 Welcome drink, reception
Friday 5 May 2023
Session 2 (9:00 - 12:30)
Chairman: Gabriella Heller
9:00 - 9:45 George Makhatadze - Rensselaer Polytechnic Institute, USA
Novel Tool for Biophysical Studies of Amyloidogenesis
9:45 - 10:30 Joan-Emma Shea - University of California, Santa Barbara, USA
Self-Assembly of the Tau Protein: Liquid-Liquid Phase Separation and Fibrillization
10:30 - 11:00 Coffee break
11:00 - 11:45 Michele Vendruscolo - University of Cambridge, UK
Targeting protein aggregation in misfolding diseases
11:45 - 12:30 Gary Pielak - University of North Carolina at Chapel Hill, USA
Protein stability in living cells & under crowded conditions in vitro
12:30 - 14:00 Lunch
Session 3 (14:00 - 18:15)
Chairman: Joan-Emma Shea
14:00 - 14:45 Ellinor Haglund - University of Hawaiʻi at Mānoa, USA
The folding and function of proteins with a complex topology
14:45 - 15:30 Wim Vranken - Vrije Universiteit Brussel, BE
Defining and predicting conformational variability
15:30 - 16:15 Mihaly Varadi - EMBL-EBI, UK
Navigating the Flood of Predicted Protein Structures: Challenges and Opportunities for Understanding Disease
16:15 - 16:45 Coffee break
16:45 - 17:30 Jiri Vondrasek - Institute of Organic Chemistry and Biochemistry of the CAS, CZ
Domain context determines function in chimeric multidomain proteins
17:30 - 18:15 Brian Baker - University of Notre Dame, USA
The structural biophysics of specificity in cellular immunity
Sponsors block (18:15 - 18:55)
18:15 - 18:30 NanoTemper
18:30 - 18:45 Peptone Ltd.
18:45 - 19:30 Dinner
19:00 - 22:00 Poster session
Saturday 6 May 2023
Session 4 (9:00 - 12:30)
Chairman: Ellinor Haglund
9:00 - 9:45 Silvio Tosatto - Università di Padova, IT
CAID 2: lessons from the second critical assessment of protein intrinsic disorder prediction
9:45 - 10:30 Benjamin Schuler - University of Zurich, CH
Probing the dynamics and interactions of disordered proteins with single-molecule spectroscopy: From disordered complexes to phase separation
10:30 - 11:00 Coffee break
11:00 - 11:45 Gabriella Heller - University College London, UK
Drugging disordered proteins using NMR and MD
11:45 - 12:30 Virginia Burger - New Equilibrium Biosciences, USA
Targeting intrinsically disordered proteins with small molecule drugs
12:30 - 14:00 Lunch
Session 5 (14:00 - 18:15)
Chairman: Virginia Burger
14:00 - 14:45 Paul Robustelli - Dartmouth College, USA
Molecular recognition mechanisms of intrinsically disordered proteins
14:45 - 15:30 Kamil Tamiola - Peptone Ltd., CH
Rational modulation of intrinsic disorder in cytokines using generative AI
15:30 - 16:15 Klara Hlouchova - Charles University, CZ
Towards artificial proteins and alternative alphabets
16:15 - 16:45 Coffee break
16:45 - 17:30 Konstantinos Tripsianes - Masaryk University, CZ
Order-disorder continuum in protein function and disease
17:30 - 18:15 Mikael Oliveberg - Stockholm University, SE
Functional optimisation of diffusive protein-protein interactions in live cells
20:00 - 23:00 Conference dinner
Sunday 7 May 2023
Departures