Invited speakers
Jane DYSON
(The Scripps research Institute, USA)
Peter WRIGHT
(The Scripps research Institute,USA)
A. Keith DUNKER
(Indiana University, USA)
Dana REICHMANN
(The Hebrew University, Israel)
Modesto OROZCO
(IRB Barcelona, Spain)
Jacqueline MATTHEWS
(University of Sydney, Australia)
Nikolay DOKHOLYAN
(University of NC, Chapel Hill, USA)
Chris CHIPOT
(University of Illinois, USA)
Mikael OLIVEBERG
(Stockholm University, Sweden)
Janusz BUJNICKI
(IMCBIn Warsaw, Poland)
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Michele VENDRUSCOLO
(Cambridge University, UK)
Alex WLODAWER
(NCI, USA)
Tomas OBSIL
(Charles University, Prague, CZ)
B. Montgomery PETTITT
(University of Texas, USA)
Edward TRIFONOV
(University of Haifa, IL)
Richard STEFL
(Masaryk University, Brno, CZ)
Neil FERGUSON
(UCD Dublin, Ireland)
Vladimir SKLENAR
(Masaryk University, Brno, CZ)
Torsten SCHWEDE
(Universitat Basel, Switzerland)
Ora SCHUELER-FURMAN
(Hebrew University, Jerusalem, IL)
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Scientific Program
Friday May 9th 2014
15:00 - 15:15
Invitation: Zdeněk Hostomsky, IOCB AS CR director
Opening: Jiri Vondrasek IOCB AS CR
Session 1. Protein-Protein Interactions
Chairman: Chris Chipot
1.1 15:15-16:00 A. Keith Dunker
Disordered Protein and Developmental Biology
1.2 16:00-16:45 Alexander Wlodawer
Plant proteins with medically important properties: structural studies of three members of the β-trefoil family that function as serine protease inhibitors or as lectins
16:45-17:00 Coffee break
1.3 17:00-17:45 Torsten Schwede
Comparative protein quaternary structure modelling using evolutionary interaction fingerprints
1.4. 17:45-18:10 Moran Jerabek-Willemsen
MicroScale Thermophoresis: Interaction analysis and beyond
18:15-20:00 Welcome drink, dinner
Saturday May 10th, 2014
Session 2. Interactions within proteins and Interactions of Proteins with ligands
Chairman: Mikael Oliveberg
2.1 8:30-9:15 Nikolay Dokholyan
Controlling allosteric networks in proteins
2.2 9:15-10:00 Jacqueline Matthews
Selectivity and synergy in binding by modular linear motifs
PPS Selected talk
10:00-10:30 Kvido Stříšovský
Structural basis of rhomboid intramembrane protease specificity and mechanism revealed by X-ray crystallographic analysis of rhomboid:substrate-peptide complexes
10:30-11:00 Coffee break
2.3 11:00-11:45 Modesto Orozco
Functional aspects of protein dynamics
2.4 11:45-12:30 Vladimir Sklenar
Intrinsically Disordered Proteins – Atomic Resolution Characterization of Transient Interactions
2.5 12:30-13:15 Ora Schueler-Furman
Peptide-mediated interactions: characterization, modeling and manipulation
13:15-14:30 Lunch
Session 3. Protein-Protein Interactions
Chairman Jane Dyson
3.1 14:30-15:15 Neil Ferguson
High resolution studies of the molecular handshake between a disordered viral protein and its human binding-partner
3.2 15:15-16:00 Peter Wright
Functional interactions of intrinsically disordered proteins in dynamic signaling networks
3.3 16:00-16:45 Chris Chipot
Efficient determination of protein-protein standard binding free energies with a computational
microcalorimeter
16:45-17:10 Coffee break
3.4 17:10-17:55 Tomas Obsil
14-3-3 proteins and mechanisms of their functions
3.5 17:55-18:35 Richard Stefl
Dynamic recruitment of processing factors to the site of transcription.
19:30 – 23:00 Poster Session
Sunday May 11th, 2014
Session 4. Protein aggregates
Chairman Peter Wright
4.1 8:30-9:15 B. Montgomery Pettitt
Aggregation, collapse and disorder: Model systems
4.2 9:15-10:00 Mikael Oliveberg
In-cell thermodynamics
PPS selected talk
10:00-10:30 Lajos Kalmar
Functional evolutuon of intrinsically disordered proteins
10:30-10:50 Coffee break
4.3 10:50-11:35 Michele Vendruscolo
Characterisation of Protein Dynamics by Combining NMR Spectroscopy and Molecular Dynamics Simulations
4.4 11:35-12:20 Dana Reichmann
Unfoldomics of the cellular stress response: How do Intrinsically disordered chaperones work?
12:20-13:30 Lunch
Session 5. Protein – Nucleic Acid Interactions
Chairman Michele Vendruscolo
5.1 13:30-14:15 Edward N. Trifonov
Strong nucleosomes - towards major revision of views on chromatin.
5.2 14:15-15:00 Janusz Bujnicki
3D Modeling of protein-RNA complex structures
5.3 15:00-15:45 Jane H Dyson
Dynamics and specificity in protein-nucleic acid interactions.
15:45-16:30 General discussion and concluding remarks
16:45-18:00 Vila Lanna- Prague Castle-Prague Castle Gardens Walking Tour
18:00-21:00 Conference dinner at Vila Richter (Prague Castle vineyard)