Scientific Program

Prague Protein Spring 2018 on subject "Proteins at Work"

Thursday May 3, 2018

Invitaion:  Zdeněk Hostomský, IOCB Prague director
Opening:  Jiří Vondrášek IOCB Prague, Mikael Oliveberg Stockholm University, Michele Vendruscolo University of Cambridge

Session 1 (18:00 - 19:30)

Chair : Mikael Oliveberg

1.1 18:00 - 18:45 Mónika Fuxreiter (University of Debrecen, HU)
Fuzziness in protein assemblies - towards a stochastic paradigm
1.2 18:45 - 19:30 Kosuke Fujishima (Tokyo Institute of Technology, JP)
Protein engineering and in vitro evolution studies for the origins of life

19:30 - 21:00 Welcome drink, reception

Friday May 4, 2018

Session 2 (9:00 - 12:30)

Chair : Jiri Vondrasek

2.1 9:00 - 9:45 Harel Weinstein (Cornell, USA)
How "proteins at work" in the membrane employ allosteric mechanisms
2.2 9:45 - 10:30 David Drew (Stockholm University , SE)
Establishing the Molecular Mechanism of Sodium/Proton Exchangers

10:30 - 11:00 Coffee Break

2.3 11:00 - 11:45 Michele Vendruscolo (Cambridge University, UK)
Protein homeostasis dysregulation in Alzheimer's disease
2.4 11:45 - 12:30 José Maria Valpuesta (Centro Nacional de Biotecnología, ES)
Hsp70: a master regulator in proteostasis ... and more

12:30 - 14:00 Lunch

Session 3 (14:00 - 17:30)

Chair : Alessandro Borgia

3.1 14:00 - 14:45 Jens Danielsson (University of Stockholm, SE)
In-cell thermodynamics: modulation of protein stability and transient interactions in the cytosol
3.2 14:45 - 15:30 Arnold Boersma (Groningen University, NL)
Designed proteins to probe the intracellular environment

15:30 - 16:00 Coffee Break

3.3 16:00 - 16:45 Bojan Zagrovic (University of Vienna, Austria)
RNA-protein interactions and the structure of the genetic code
3.4 16:45 - 17:30 Alan Jasanoff (MIT, USA)
Engineering magnetically active proteins for imaging the brain

17:30 - 18:30 Dinner buffet

18:30 - 19:30 Sponsors block

Lutz Ehrhardt (Beckman Coulter) Analytical Ultracentrifugation 
Giuseppe Tortoriello (Thermo Fisher Scientific) iBright imaging system

19:30 - 22:00 Poster Session

Saturday May 5, 2018

Session 4 (9:00 - 12:30)

Chair : Amnon Horovitz

4.1 9:00 - 9:45 Christine Orengo (University College London, UK)
How proteins evolve - CATH FunFam insights on functional innovation
4.2 9:45 - 10:30 Rob Finn (EMBL-EBI, UK)
Bioprospecting for novel proteins in metagenomics dataset - fact or fiction?

10:30 - 11:00 Coffee Break

4.3 11:00 - 11:45 José Onuchic (Rice, USA)
Exploring protein function: the convergence of structure based models and co-evolutionary information
4.4 11:45 - 12:30 Marek Jindra (Biology Center CAS, CZ)
The curious receptor for the "hormone of youth"

12:30 - 14:00 Lunch

Session 5 (14:00 - 17:30)

Chair : Christine Orengo

5.1 14:00 - 14:45 Amnon Horovitz (Weizmann Institute, IL)
Chaperonin nano-machines: allostery and function
5.2 14:45 - 15:30 Gary Drobny (UW Seattle, USA)
Spectroscopic Studies of Protein Structure and Dynamics at Biomineral Interfaces

15:30 - 16:00 Coffee Break

5.3 16:00 - 16:45 Petter Lyngstaadas (University of Oslo, NO)
Dental enamel; protein templated biomineralization in a complex hierarchical biological system
5.4 16:45 - 17:30 Jan Procházka (IMG Prague, CZ)
Ameloblastin: too many roles of enamel specialized protein?

19:00 - 23:00 Conference Dinner at Restaurant Vozovna Stromovka

Sunday May 6, 2018

Session 6 (9:00 - 11:45)

Chair : Harel Weinstein

6.1 9:00 - 9:45 Alessandro Borgia (University of Zurich, CH)
A new paradigm for biomolecular interactions: ultrahigh-affinity complex of two intrinsically disordered proteins involved in chromatin remodeling
6.2 9:45 - 10:30 Gideon Schreiber (Weizmann Institute, IL)
How to proteins function within the crowded cellular milieu

10:30 - 11:00 Coffee Break

6.3 11:00 - 11:45 Magnus Wolf-Watz (Umeå University, SE)
Positive and Negative Substrate Interference Supported by Coinciding Enzyme Residues